花生多肽对正常小鼠免疫功能的影响

Immunity Adjustment Ability of Peanut Polypeptides on Mice

通过动物试验,测定2,4-二硝基氟苯(DNFB)致敏的迟发性超敏反应、自然杀伤细胞(NK cell)活性、血清免疫球蛋白(IgG)含量、白介素-1(IL-1)含量和腹腔巨噬细胞吞噬功能,并在光学显微镜下观察免疫器官的形态学变化。结果表明:中、高剂量的花生多肽能够调节迟发性超敏反应和NK细胞活性,增加IL-1和血清IgG的含量,提高腹腔巨噬细胞吞噬能力。这说明中、高剂量的花生多肽能显著提高机体的免疫能力。

The aim of this work is to evaluate the immunity adjustment of peanut polypeptides with mice as test animals. Results： A middle or high dosage of peanut polypeptides can improve the nonspecific and specific immune ability of mice. Peanut peptides exhibit obvious action on promoting the reaction ability of delayed type hypersensitivity （DTH） and the level of natural killer （NK） cell activity, increasing the content of serum IgG and the standard of interleukin I（IL- 1 ）, and raising the phagocytize rate of peritoneal macrophage in mice.