2型糖尿病患者血清直接胆红素水平与心血管疾病的相关性

The Relationship between Serum Concentration of Direct Bilirubin and Cardiovascular Disease in Type 2 Diabetes Patients

目的探讨2型糖尿病患者血清直接胆红素(D-Bil)水平与心血管疾病(CVD)的相关性。方法回顾性分析280例2型糖尿病住院患者的临床资料,按照有无CVD分为糖尿病合并CVD组与糖尿病非CVD组,比较两组年龄、性别、可追溯糖尿病病程、吸烟、体质指数(BMI)、D-Bil、糖化血红蛋白(HbA1C)、血脂、血压,应用Logistic回归分析D-Bil与CVD的相关性。结果糖尿病合并CVD组年龄、可追溯糖尿病病程、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、低密度脂蛋白(LDL)高于非CVD组,D-Bil低于非CVD组(P<0.05);在调整了年龄、可追溯糖尿病病程、SBP、DBP、HbA1C、TC、LDL后,D-Bil与CVD呈负相关(OR=0.854,95%CI:0.737～0.990)。结论2型糖尿病患者D-Bil的降低可能是糖尿病合并CVD的独立危险因素之一。

Objective To investigate the relationship between the serum concentration of direct bilirubin（D-Bil） and cardiovascular disease（CVD） in type 2 diabetes mellitus patients. Methods The clinical data of 280 eases with type 2 diabetes mellitus was retrospectively analyzed, and they were divided into two groups of diabetes mellitus with and without CVD and compared with their age, gender, traceable diabetes mellitus course, smoking, body mass index（BMI）, D-Bil, hemoglobin A1c （HbA1c）, blood lipids and blood pressure. The correlation of D-Bil and CVD was analyzed with Logistic analysis. Results The traceable diabetes mellitus course, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, total cholesterol （TC）, low density lipoprotein （LDL） of CVD group were significantly higher than those of non-CVD group, while D-Bil was significantly lower than that in non-CVD group（P〈0.05）; After the adjustment by age, sex, smoking, traceable diabetes mellitus course, SBP, DBP, HbAc, TG, TC,HDL and LDL,D-Bil was negatively correlated with CVD（OR=0.854,95% CI：0.737-0.990）.Condusion The low concentration of serum D-Bil is one of the risk factors for complication of CVD in patients with type 2 diabetes mellitus.