糖尿病肾病患者血清sCD40L与HbA1c分析的临床意义

ANALYSIS OF SENRUM SCD401 AND HBA1C CONTENTS IN PATIENTS WITH DIABETES NEPHROPATHY

目的:探讨糖尿病肾病(diabetes nephropathy,DN)患者血清可溶性CD40配体(solubleCD40ligand,sCD40L)水平变化及其临床意义。方法:根据尿微量清蛋白排泄(UAER)将92例2型糖尿病患者分为单纯糖尿病(A)组、早期糖尿病肾病(B)组和临床糖尿病肾病(C)组,别选30例健康体检者作为对照(D)组,分别测定各组血清sCD40L和HbA1c水平。结果:4组之间血清sCD40L和HbA1c水平有明显的差异(P<0.05)且血清sCD40L和HbA1c水平呈正相关(r=0.89,P<0.01)、HbA1c与UAER相关(r=0.56,P<0.05)。结论:DN患者血清sCD40L水平升高,且与HbA1c水平呈正相关,sCD40L、HbA1c与糖尿病肾病密切相关。

Objective：To investigate the changes and the clinical significance of serum soluble CD40 ligand（sCD40L） contents in Patients with Diabetes nephropathy. Methods：Fasting soluble CD40 ligand（sCD40L） and HbA1c, and urine albumin of various diabetic groups were measured. The relativity and differences between these data were analyzed. Results：Compared with control group, serum level of sCD40L and HbA1c were distinctly higher（ P 〈 0.05 ）, and correlation analysis suggested that serum of leve sCD40L was positively correlated with HbAlc （ r = 0.89, P 〈 0.01 ） and HbA1 c was positively correlated with UAER （ r = 0.56, P 〈 0.05 ）. Condusiob：The serum sCD40L of level is distinctly higher, and was positively correlated with HbA1 c and is closely related to Diabetes nephropathy.