人多效蛋白对肺癌早期诊断的价值

Early diagnostic value of human pleiotrophin in lung cancer

目的评价肿瘤标志物多效蛋白(PTN)对肺癌早期诊断的价值。方法采用特异性酶联免疫吸附试验对11例小细胞肺癌(SCLC)及50例非小细胞肺癌(NSCLC)的血清PTN水平进行检测,并与17例肺部良性病变及10例健康者进行比较。结果PTN在健康者血清中微量存在;在肺部良性病变、NSCLC及SCLC患者的血清中浓度呈梯度上升,差异均具有统计学意义(均P<0.01)。血清PTN对SCLC灵敏度、特异度分别达90.9%和94.1%。结论PTN是一种有效检测肺癌的标志物,尤其在SCLC的血清中升高更明显,因此血清PTN可作为早期诊断SCLC的指标。

Objective To evaluate the diagnostic value of the tumor marker of pleiotrophin （PTN） in patients with lung cancer. Methods The levels of PTN was measured by enzyme-linked immunosorbent assay （ELISA） in serum of 11 patients with small cell lung cancer （SCLC）, 48 patients with non-small cell lung cancer（NSCLC） , 17 patients with benign lung lesion disease and 10 healthy controls. Results A low amount of PTN can be measured in healthy controls. The levels of PTN in patients with benign lung disease, NSCLC and SCLC were gradiently increased （P 〈0.01 ）. The sensitivity and specificity of PTN in patients with SCLC were 90.9% and 94. 1% respectively. Conclusion PTN in serum has the important early diagnostic values in detecting lung cancer, especially in SCLC.