VEGF、Ki-67在子宫内膜腺癌中的表达及相关性研究

Expression and Relevant Research of Ki-67,VEGF in Endometrium Adenocarcinoma

目的探讨血管内皮生长因子(VEGF)和细胞增殖核抗原(K i-67)在子宫内膜病变中的表达及其相关性。方法采用免疫组化SP法检测VEGF与K i-67在正常内膜、非典型增生内膜及子宫内膜腺癌中的表达,并分别比较其与子宫内膜腺癌组的各临床病理指标之间的关系。结果VEGF、K i-67在子宫内膜腺癌中的表达均高于前2组,差异有显著性。VEGF的表达水平与肿瘤的分化程度及淋巴结转移有关,K i-67的表达与肿瘤淋巴结转移之间的差异无统计学意义,而与手术病理分期、分化程度及肌层浸润深度之间有统计学意义,且K i-67与VEGF呈正相关。结论VEGF和K i-67可能共同促进肿瘤细胞的增殖、分化,对子宫内膜癌的发生、发展具有重要作用,并可能成为判断子宫内膜癌预后的重要指标。

Objective To analyze vascular endothelial growth factor （VEGF） and cell multiplication nuclear antigen （Ki-67）, and to study the relevance expression in endometrium adenocarcinoma. Methods Using SP law to examine VEGF and Ki-67 in the normal internal membrane, non-typical pro- liferation internal membrane and the expression in endometrium adenocarcinoma. The relations between clinical pathology targets were compared separately. Results Both are higher than the normal and non- typical groups,and the difference was significant. VEGF expression level was related with the degree of tumor differentiation and lymph transfer. There was no significance between the expression of Ki-67 and lymph transfer but there was significance between surgical-pathological staging, differentiation and the depth of myometrial invasion and Ki-67 and VEGF were directly correlated. Conclusion VEGF and Ki- 67 can promote the multiplication of tumor cell and the differentiation. The development plays influential role and becomes the important target in judging the endometrium cancer prognosis.