利托君防治早产的效果观察

The study of the effect of ritodrine in the premature labor

目的：观察利托君抑制子宫收缩的效果及副作用,探讨其临床应用价值。方法：将100例早产（包括先兆早产）孕妇分为观察组和对照组。观察组60例给予利托君静脉滴注,以0.05 mg/min逐渐调整滴速至子宫收缩完全停止后再维持12-18h,然后改为口服维持7天。对照组40例给予硫酸镁4 g于30 min左右静脉滴注完毕,然后改为1-2 g/h静脉滴注至子宫收缩完全抑制。比较两组保胎成功率、延长孕周时间、抑制子宫收缩的显效时间、低钾血症发生率、心率变化、产后出血发生率以及对围生儿的影响。结果：观察组保胎失败率为11.7%,对照组为12.5%;观察组延长孕周（1.00±0.7）周,对照组延长孕周（0.87±0.6）周,两组差异均无统计学意义（P〉0.05）。观察组抑制子宫收缩显效时间短于对照组（P〈0.05）,低钾血症发生率高于对照组（P〈0.01）。两组产后出血率、新生儿体重、新生儿Apgar评分差异均无统计学意义（P〉0.05）。结论：利托君抑制早产孕妇的子宫收缩疗效确切,显效快,但需注意防范低血钾等副作用。

Objective： To determine the effect and side effect of ritodrine in the premature labor and investigate the clinical significance. Methods： One hundred cases of premature labor were randomly divided into observation group and control group. Observation group consisted of 60 cases were given with ritodrine at 0.05 mg/min concentration firstly, and the concentration was added gradually until the uterine contraction was vanished and the medication was continued for 12 -18 hours, then the medicine taken orally last for 7 days. Control group consisted of 40 cases were given with magnesium sulfate intravenously, the first 4 g was given within 30 minutes, then 1 - 2 g per hour was given until the uterine contraction was vanished. The success rate of fetus protection, the time of uterine contraction vanished, the incidence of hypopotassaemia, the changes of heart rate, the effect of prolong gestational age, the rate of postpartum hemorrhage rate,neonatal weight and the Apgar score were compared between the two groups. Results：Percent of failure cases is 11.7% in observation group and 12.5% in control group;prolong gestational age is （1.00 ±0. 7）week in observation group and （0.87 ±0.6 ） week in control group, which was shown no significant difference between two groups （P 〉 0.05 ）. The time of uterine contraction vanished in observation group was shorter than in control group （ P 〈 0.05 ）. The incidence of hypopotassaemia was higher in observation group （P 〈0. 01 ）. The rate of postpartum hemorrhage,neonatal weight and the Apgar score were no significant difference. Conclusions：Ritodrine can inhibit uterine contraction of pregnant woman which prevent the occurance of premature labor effectively, but the incidence of hypopotassaemia and other side effects will be cautioned.