金黄色葡萄球菌对16种抗菌药物的耐药性分析

Antimicrobial resistance analysis of staphylococcus aureus to sixteen types antibiotics

目的探讨临床感染标本金黄色葡萄球菌对抗菌药物的耐药状况，为临床合理使用抗菌药物提供参考依据。方法调查统计2006年1月至2008年11月实验室分离的金黄色葡萄球菌，采用纸片扩散法（K-B法）测定16种抗菌药物的药物敏感试验数据，用WHONET5软件进行统计分析。结果239株金黄色葡萄球菌，其中耐甲氧西林金黄色葡萄球菌（MRSA）为133株，占55．6％；甲氧西林敏感金黄色葡萄球菌为106株，占44．4％；金黄色葡萄球菌对16种抗菌药物的耐药率最高的是青霉素G为224株（93．8％）、万古霉素耐药率为0。结论甲氧西林敏感金黄色葡萄球菌对大部分抗菌药物仍保持良好的敏感性，而耐甲氧西林金黄色葡萄球菌表现为多重耐药性，但万古霉素例外，所以对耐万古霉素金黄色葡萄球菌的连续监测、了解葡萄球菌属的耐药机制具有重要的临床意义。

Objective To discuss antibiotic resistance of the clinical samples infected with Staphylococcus anreus. Methods The laboratory data of resistant Staphylococcus aureus from Jan 2006 to Nov 2008 were investigated and antibiotic sensitivity was determined by K-B method. The data was analyzed with the soft WHONETS. Results Among Staphylococcus aureus strains, the meticillin-resistant Staphylococcus aureus （MRSA） was 133 （55.6%）. the meticillin-sensitive Staphylococcus aureus（MSSA） wasl06 accounting for （44.4%）. The resistant rate of Staphy- lococcus aureus to penicillin G was the highest（93.8% ）. Conclusion MSSA still keeps fairly good sensibility to most antibacterial medicine, but MRSA shows multidrug resistance.