外周血淋巴细胞计数对评价婴幼儿流感样病例的临床意义

Clinical study of peripheral blood lymphocyte count in influenza-like children

目的通过检测流感样患儿外周血淋巴细胞计数的变化，探讨其在评价流感样患儿疾病发展和预后的意义。方法回顾性分析125例6个月-3岁流感样患儿的临床资料，按照有无并发症分为轻症组80例和重症组45例。对照组55例为同期行体格检查的正常儿童。比较3组血淋巴细胞亚群、红细胞沉降率、C反应蛋白以及2组患儿早期和治愈出院时的淋巴细胞计数，并进行统计学分析。结果重症组患儿的早期淋巴细胞总计数[（2．54±1．67）×10^9／L]、红细胞沉降率[（20．17±12．91）mm／h]、CD3＋[（1．65±0．68）×10^9／L]、CD4^＋[（0．87±0．48）×10^9／L]、CD4／CD8[（0．96±0．41）×10^9／L]与轻症组及对照组比较，差异有统计学意义（P〈0．05或P〈0．01）；C反应蛋白在轻症、重症患者间比较，差异无统计学意义；2组出院时淋巴细胞计数差异无统计学意义。结论重症流感样患儿体内存在暂时T细胞免疫功能紊乱，早期外周血淋巴细胞计数降低，病情重，易出现并发症。

Objective To study the value of peripheral blood lymphocyte count in influenza-like children. Methods Clinical data of 125 acute upper respiratory infection infants aged from 6 months to 3 years was reviewed. The patients were divided into two groups： none-complication group and complication group. Healthy children were enrolled as the control group. Lymphocyte subsets, erythrocyte sedimentation rate（ESR） ,C-reactive protein （CRP） and the count of peripheral blood lymphocyte of early stage and curing stage were analyzed. Results The count of peripheral blood lymphocyte of early stage, CD3＋ , CD4＋ , CD4/CD8 and ESR rate in complication group were significantly lower than those in none-complication group and control group respectively. But the CRP levels showed no significant difference between both groups. Conclusion The count of peripheral blood lymphocyte of influenzalike children of complication group is low at early stage.