血清胱蛋白酶抑制剂C在老年2型糖尿病患者早期肾功能损害诊断中的价值

The diagnosis's value of serum cystatin C in the elderly patients with type 2 diabetic early renal damage

目的探讨血清胱蛋白酶抑制剂C(CysC)在老年2型糖尿病患者早期肾功能损害诊断中的价值。方法将45例平均年龄83岁2型糖尿病住院患者,采用胶乳增强免疫比浊法检测血清胱蛋白酶抑制剂C,同时检测血清肌酐(Scr)、血清尿素氮(Bun)、尿肌酐(Ucr),β2微球蛋白(β2-MG),推算肌酐清除率(Ccr),比较两组患者Bun、Scr、Ccr、CysC、β2-MG,两组各检验方法阳性率结果比较。结果两组患者Bun、Scr、Ccr、CysC、β2-MG之间有统计学差异(P<0.01);在糖尿病组,CysC法阳性率为55.5%,Ccr法阳性率为86.7%,β2-MG法为60%(P<0.001),CysC法与β2-MG法阳性率接近。CysC与Scr、Ccr、β2-MG的相关性分析有统计学意义。结论CysC能够及早发现糖尿病肾病患者肾功能的变化,对其早期的诊断有意义,是一个有价值的指标。

Objective To explore the serum cystatin C （Cys C） in elderly patients with type 2 diabetic diagnosis of elderly renal dysfunction in value. Methods 45 cases of the average age of β2-year-old patients with type 2 diabetic,using latex enthods immunoturtric assay of serum cystatin C,while serum creatinine （Scr）,blood ureanitrogen（Bun）,urine crea- tinine （Ucr）,β2-microglobulin （β2-MG）,estininie clearance rat （Ccr）,compared two group of patients with Bun,Scr,Ccr, Cys C,β2-MG,were positive rate of the testresuts. Results The two groups of patients with Bun,Scr,Ccr,Cys C,β2-Mg significant difference （P〈0.01）,in the diabetic group,the positive reat of Cys C method for 55.5%,Ccr method positive reat of 86.7%,β2-Mg method for 60%（P〈0.001）,Cys C method and β2-Mg positive reat close. Cys C and Scr,Ccr,β2-MG analysis of the relevance of statistical significance. Conclusion Cys C to elderly detection of diabtic nephropathy in patients with renal function changes in early diagnosis of its significance,is a valuable indicator.