不同化疗方案治疗晚期胃癌的疗效观察

Comparative study of different chemotherapy regimen in patients with advanced gastric cancer

目的比较FOLFOX、CF、DCF三种化疗方案治疗晚期胃癌的效果。方法回顾分析173例分别采用FOLFOX、CF及DCF3种治疗方案的初治晚期胃癌患者:其中采用FOLFOX方案治疗71例,CF方案59例,DCF方案43例。每28天为1个疗程,至少完成2个周期的化疗后,评估患者的近期疗效和毒副反应。结果3种方案的近期疗效分别为:FOLFOX方案31.0%,CF方案27.1%,DCF方案55.8%,DCF方案疗效明显高于其他两个方案,差异有统计学意义(P<0.01)。毒副反应主要为骨髓抑制和消化道反应,DCF方案发生几率较高,但患者均可耐受,差异无统计学意义(P>0.05)。结论晚期胃癌患者应用DCF方案近期疗效较好,不良反应可以耐受,值得临床推广使用。

Objective Different chemotherapy regimen in patients with advanced gastric cancer were been compared on the clinical effect. Methods 173 patients with advanced gastric cancer were Divided into 3 groups,and each group patients were treated By different chemotherapy regimen,FOLFOX,CF or DCF. Curative effect and adverse reaction were compared among the patients of these three groups after 2 cycles＇ chemotherapy. Results The short-term response rate of 3 group were 31.0% ,27.1% and 55.8% respectively. DCF regimen achieved a higher effective rate than that of CF or FOLFOX （P〈0.01）;The main adverse reaction includes leucopenia and gastrointestinal reaction. The incidence of toxicity reaction was more frequent in patients accept DCF regimen,but there were no significant difference among the three group. Conclusion DCF combination chemotherapy is an effective and tolerable regimen in patients with advanced gastric cancer.