老年人泌尿系感染主要致病菌的耐药性分布

Bacterial group examine and drug resistance analysis of senile urinary tract infection

目的探讨老年人泌尿系感染的主要致病菌的耐药性分析,以指导临床合理用药。方法回顾整理老年泌尿系感染患者250例,对其中段尿培养及药敏试验资料进行统计学分析。结果分离出186株病菌,其中大肠埃希氏82例,占44.08%;其次是铜绿假单胞菌38例,占20.43%;不动杆菌19例,占10.21%。对居首位的致病菌大肠埃希氏菌进行了11种抗生素的药敏试验,结果显示亚胺培南和丁胺卡那敏感性最高,为100%,部分青霉素类及头孢类抗生素敏感性已趋于下降,而喹喏酮类药物,对G+菌和G-菌的耐药率已达50%以上。结论引起老年人泌尿系统感染的细菌多为条件致病菌,以革兰氏阴性杆菌为主,其耐药性在不断变化,故应根据药物敏感试验的结果,合理选择使用抗生素,以尽可能减少耐药菌株的产生。

Objective To investigate the detection of pathological bacteria and their drug resistance of Senile Urinary Tract Infection,so as to guide clinical rational drug use. Methods Studied all the midstream culture of urine and drug sensitive test documents of senile urinary tract infection patients. Results Separated 186 bacterial strains , 44.08% were Escherichia coli,20.43% were Pseudomonas aeruginosa and 10.21% were Acinetobacter. The sensitive rate of Eseheriehia coli to Imipenem and Amikacin were separately 100%,Drug resistance rate of Escherichia coli to Levofloxacin was 76.3%. Conclusion Senile Urinary Tract Infection still take Gram negativebacteria as the major cause,and their drug resistance has been changed. Clinician should strengthen the detection of pathogens and drug resistance monitoring,in order to choose effective and pertinence antibiotic and reduce drug-resistant strains.