恶性滋养细胞肿瘤化疗栓塞疗效观察

Clinical observation of chemo-embolization for treating malignant trophoblastic tumors

目的观察用夹心疗法治疗恶性滋养细胞肿瘤的疗效。方法采用Seldinger方法股动脉穿刺,经髂内动脉超选择性插入子宫动脉,进行先栓塞后注入化疗药,再栓塞的方法。结果5例患者经过2～3次治疗获得了满意疗效。结论夹心疗法是用明胶海绵颗粒及条混悬液栓塞远端末梢血管和近端主干,其中间注入化疗药的疗法,使肿瘤供血动脉局部保持持续较高的药物浓度。可进一步提高效果,且毒副作用明显减轻,完全可替代无全身转移的全身化疗。

Objective To observe the clinical effects of sandwich therapy in treating malignant trophoblastic tumors. Methods： After adopting the Seldinger technique to puncture the femoral artery, inserting the uterine artery through internal iliac artery super-selection, the patients were emholized and injected chemotherapeutic drugs then reembolizing. Results： Five patients got satisfied effects after 2-3 treatments. Conclusion： Gelatinous sponge particles and article suspension were used to embolize the distal peripheral vessels as well as the proximal trunk, in which chemotherapeutic drugs were injected, making the tumor blood supply artery keep high drug concentration. The therapy could improve the effects, shorten the periods of treatment and reduced side effects. It could replace the non-metastatic systemic chemotherapy.