经埋置式皮下动脉化疗泵治疗乏血供转移性肝癌的临床应用

Clinical application of subcutaneously embedded arterial chemotherapy pump for metastatic hepatic carcinoma lack of blood supply

目的探讨经埋置式皮下动脉化疗泵实施肝动脉化疗治疗乏血供转移性肝癌的方法和疗效。方法26例经CTA、DSA证实的乏血供转移性肝癌患者均行化疗泵植入术,术中及术后经泵注入肝动脉化疗药物。术后观察病情变化,并定期复查肝功、CEA定量、CT或B超检查以评价疗效。结果所有患者临床上均有不同程度的症状减轻,21例(82%)患者术后2～3周复查肝功明显好转,13例(52%)患者肿瘤缩小。半年、一年、两年的生存期分别是82%、68%、47%。结论经埋置式皮下动脉化疗泵治疗乏血供转移性肝癌有术式简单、选择性强、避免股动脉重复插管、给药简便、并发症少等优点,对乏血供转移性肝癌的治疗是可行的。在延长患者生存期,提高生存质量,最大程度的缓解病情方面具有一定的意义,疗效可靠。

Objective： To investigate the method and efficacy of hepatic arterial chemotherapy by chemotherapy pump for metastatic hepatic carcinoma lack of blood supply. Methods： Chemotherapy pump was applied to 26 patients with metastatic hepatic carcinoma lack of blood supply confirmed by DSA or CTA. Meanwhile and after that, regular hepatic arterial infusion chemotherapy was performed by the pump. All patients were followed up at least two years. Results： Symptoms were improved in all patients. In the second and third weeks after first chemotherapy, Liver function was markedly promoted in 21 cases （82%） and liver metastases grew downwards in 13 cases （52%）. The half-, 1- and 2-year cumulative survival rates were 82%, 68% and 47%, respectively. Conclusions： Metastatic hepatic carcinoma lack of blood supply treated by chemotherapy pump can easily be operated, and can reduce complications as expected. It also can prolong life span and enhance the live quality of patients.