调节性T细胞与乙型肝炎病毒感染的研究进展

Research Progress about Regulatory T Cells and HBV Infection

根据来源可将调节性T细胞分为天然调节性T细胞和获得性调节性T细胞,其表达多种特殊标志物,如CD25、CD127、Foxp3等,其中最具特异性的是Foxp3。慢性乙型肝炎病毒(HBV)感染者体内的调节性T细胞的频率升高,与HBV DNA载量、HBeAg呈正相关,并且能抑制HBV抗原特异性细胞毒性T淋巴细胞增殖和细胞因子分泌,在慢性乙型肝炎的发病中起重要作用。

Regulatory T cells（ T regs）can be divided into the nature group and the induced group based on the different origins. There are many markers expressed in them,including CD25 ,CD127 and Foxp3 et al, and the most specific one is the Foxp3. A high frequency of T regs can be found in the blood and liver of chronically HBV infected subjects, it is positive correlate with HBV DNA level and HBeAg level. HBV specific T regs can suppress the proliferation and interferon production of HBV specific CD8＋ T cells, so they play an important role in HBV infection.