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AT1-AA和sFlt-1与子痫前期的关系

Relation of Agonistic Autoantibody to the Angiotensin Ⅱ Type 1 Receptor,Soluble Fms-Like Tyrosine Kinase-1 with Preeclampsia
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摘要 血管紧张素Ⅱ1型受体自身抗体(AT1-AA)通过类血管紧张素Ⅱ的激动效应,激活活性氧簇和炎性反应,使滋养细胞侵袭变浅,胎盘血流量减少和胎盘血管硬化。可溶性血管内皮生长因子受体1(sFlt-1)使机体处于抗血管发生状态,滋养细胞浅植入和不正常的子宫胎盘血管抵抗。AT1-AA可能促进sFlt-1的产生,共同参与子痫前期的发病。深入研究AT1-AA和sFlt-1的相关性,对了解子痫前期的发病机制及预测、预防具有十分重要的意义。 Angiotensin Ⅱ type 1 receptor agonistic antibodies activate reaction oxygen species and inflarnmatory response,inhibit trophoblast invasion, reduce perfusion and lead to placental-bed arteriolosclerosis. Soluble Fms-like tyrosine kinase-1 contributes to anti-angiogenesis, inadequate trophoblast implantation and abnormal placenta vascular resistance. AT1-AA induce sFlt-1 expression and involves in the pathophysiology of preeclampsia. It is important to investigate the possible correlation between AT1-AA and sFLT-1.
作者 邱中原 胡继芬
机构地区 福建医科大学附属第一医院妇产科
出处 《医学综述》 2009年第17期2578-2580,共3页 Medical Recapitulate
关键词 子痫前期 血管紧张素Ⅱ1型受体自身抗体 可溶性血管内皮生长因子受体1 Preeclampsia Angiotensin Ⅱ type 1 receptor agonistie antibodies Soluble fms-like tyrosine kinase-1
分类号 R714.24 [医药卫生—妇产科学]
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参考文献29

  • 1Fu ML, Herlitz H, Schulze W, et al. Autoantibodies against the angiotensin receptor( AT1 ) in patients with hypertension [ J ]. J Hypertens,2000,18(7) :945-953.
  • 2Fu ML, Herlitz H, Wallulat G, et al.Non-desensitized positive chronotropic effect of anti-angiotensin Ⅱ receptor autoantibodies in patients with malignant hypertension [ J ]. Circulation, 1996, 106 (14) :4046-4047.
  • 3Wallukat G, Homuth V, Fischer T, et al. Patients with preeclampsia develop agonisitic autoantibodies against the angiotensin AT1 receptor[ J ]. J Clin Invest, 1999,103 (7) :945-952.
  • 4Hubel CA, Wallukat G, Wolf M, et al. Agonistic angiotensin Ⅱ type 1 receptor autoantibodies in postpartum women with a history of preeclampsia [ J]. Hypertension ,2007,49 (3) :612-617.
  • 5Wallukat G, Neichel D, Nissen E, et al. Agonistic autoantibodies directed against the angiotensin Ⅱ AT1 receptor in patients with preeclampsia[ J ]. Can J Physiol Pharmacol,2003,81 ( 2 ) : 79 -83.
  • 6Stepan H, Faber R, Dornhofer N, et al. New insights into the biology of preeclampsia[ J]. Biol Reprod ,2006,74 ( 5 ) :772-776.
  • 7吴超英,朱剑文,邓飞涛,王泽华.抗血管紧张素Ⅱ受体1型自身抗体在妊高征发病机制中的作用[J].中华围产医学杂志,2004,7(4):206-208. 被引量：2
  • 8Wang B, Liao YH, Zhou Z, et al. Arterial structure changes in rats immunized by AT1 - receptor peptide [ J ]. Heart Vessels,2005,20 (4) :153-158.
  • 9Theingi MT, Sergiy GS, Mary-Clare D, et al. Antibodies from pre-eclamptic patients stimulate increased intracellular Ca^2+ mobilization through angiotensin receptor activation[ J ]. Circulation,200d, 110(12) :1612-1619.
  • 10Wahher T,Wallukat G,Jank A,et al. Angiotensin Ⅱ type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature [ J ]. Hypertension,2005,46 (6) : 1275-1279.

二级参考文献5

  • 1Hoebeke J. Structural basis of autoimmunity against G protein coupled membrane receptors. Int J Cardiol,1996,54:103-111.
  • 2Wallukat G, Homuth Ⅴ, Fischer T, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest,1999,103:945-952.
  • 3Dechend R, Homuth Ⅴ, Wallukat G, et al. AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation, 2000,101:2382-2387.
  • 4AbdAlla S, Lother H, el Massiery A, et al. Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin Ⅱ responsiveness. Nat Med, 2001,7:1003-1009.
  • 5魏宇淼,廖玉华,王敏,董继华,王朝晖,程龙献.抗血管紧张素Ⅱ受体1型和α_1-肾上腺素受体自身抗体在高血压患者检测结果分析[J].中华心血管病杂志,2002,30(6):321-324. 被引量：20

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医学综述
2009年 第17期

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