山莨菪碱治疗小儿非感染性腹泻疗效观察

Therapeutic Observation of Children′s Noninfectious Diarrhea with Anisodamine

目的观察山莨菪碱治疗小儿非感染性腹泻的临床疗效及安全性。方法将270例非感染性腹泻患儿随机分为2组:对照组140例给予补液,纠正水、电、酸碱紊乱等常规治疗,治疗组130例加山莨菪碱静脉滴注。结果治疗组显效80例,有效30例,无效20例。对照组显效35例,有效55例,无效50例。两组之间比较差异有统计学意义(P<0.01)。结论山莨菪碱治疗小儿非感染性腹泻疗效显著,使用安全,值得推广。

Objective To observe the curative effect and safety of anisodamine on children＇s non-infectious diarrhea. Methods 270 cases with non-infectious diarrhea were divided into 2 groups randomly. The control group（n = 140）was treated with conventional therapy such as fluid replacement, balancing hydro-electrolytic and acid base disorder. The therapy group （ n = 130 ） was given anisodamine intravenous drip on the basis of conventional therapy. Results Therapeutic group achieved obviouse therapeutic effect in 80 cases,just therapeutic effect in 30 cases, and no effect in 20 case. Control group achieved obviously effect in 35 cases ,just effect in 55 cases and no effect in 50 cases. The two groups had a significant difference（P 〈0.01 ）. Conclusion Treating children＇s non-infectious diarrhea with anisodamine is effective and safty. The method is worth popularizing and applying.