摘要
目的:观察川芎嗪对豚鼠乳头状肌机械电话动和猪冠状动脉收缩的影响。方法:标准玻璃微电极技术、电生理方法、血管灌流方法。结果:①川芎嗪(3.0μmol/L~100μmol/L)对豚鼠乳头状肌快反应电位(FAP)的时程(APD)、收缩力(FC)和慢反应电位(SAP)的幅度(APA),APD,FC及最大去极速度(Vmax)均呈剂量依赖性抑制;②川芎嗪(3.0mmol/L)可以在高钾去极、钠通道失活的豚鼠乳头状肌标本上诱发产生SAP及FC,这一现象可被β受体阻断剂所阻断。[Ca2+]o增加,川芎嗪诱发SAP的APA随之增加;③川芎嗪(10-5mol/L~5×10-3mol/L)对高钾去极化收缩的猪冠状动脉环呈舒张作用,且不被β受体阻断剂所阻断和[Ca2+]o增加的影响。结论:提示川芎嗪可能通过β受体影响心肌细胞慢内向电流。川芎嗪对冠状动脉有舒张作用。
Objective:To study the effects of ligustrazine on mechanical electricity in guinea pig ventricular papillary muscles and on contraction of pig coronary artery.Method:Standard glass microelectrode technology;electrophysiological method;and blood vessel perfusion were used.Result:①ligustrazine(3~100μmol/L)suppressed the action potential duration (APD)and the force of contraction (FC) of the fast action potentials (FAP),as well as the action potential amplitude (APA),APD,FC and the maximal upstroke velocity(Vmax)of the slow action potentials (SAP).② ligustrazine (3.0 mmol/L)induced SAP and contraction, but failed in betaadrenoreceptor blocked muscles.Elevation of[Ca2+]o increased the action potential amplitude (APA).③ligustrazine(10-5~5×10-3mol/L)decreased the contractile response to high KCl in pig coronary artery. Conclusion: Ligustrazine might affect the inward current of myocardial cells through betaadrenoreceptor,and the diastolizing effect of ligustrazine on coronary artery might have nothing to do with the exciting betaadrenoreceptor.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1998年第8期491-493,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金
河南省科委科学基金
关键词
川芎嗪
动作电位
乳头状肌
冠状动脉
ligustrazine
action potential
papillary muscles
coronary artery