摘要
目的:观察大果木姜子油(CV3)抗实验性心律失常作用。方法:采用氯仿、肾上腺素(Adr)、毒毛旋花子甙K(毒K)、氯化钡(BaCl2)建立小鼠、家兔、豚鼠、大鼠心律失常模型,随机分对照组、CV3组、慢心律组(MXL),观察各组对抗心律失常作用。结果:CV3组能显著降低氯仿致小鼠室颤发生率;推迟及缩短Adr致家兔心律失常发生时间及持续时间,提高毒K致豚鼠心律失常剂量;降低BaCl2致大鼠各类心律失常发生率及各类型评分,减慢心率。结论:CV3具有对抗实验性心律失常作用。作用机理与CV3阻止心肌细胞膜Na+,Ca2+内流、降低其自律性。
Objective:To investigate the effects of Cinnamomum migao on experimental arrhythmia.Method:Arrhythmic models of mice,rabbits,guinea pigs and rats were built using chloroform(Chl),adrenalin(Adr),strophanthinK (SptK)and barium chloride (BaCl2).The affected animals were divided randomly into three groups: control group,Cinnamomum migao (CV3)group and mexiletine (MXL)group,so as to observe and compare the antiarrhythmic effects.Result:CV3 could reduce the incidence of venticular fibrillation caused by ch1 in mice and the ventricular tachycardia induced by Adr in rabbits, delay the onset time of this arrhythmia.increase the arrhythmic doses of SptK in guinea pigs,reduce the incidence of some arrhythmia caused by BaCl2 in rats and slow down their heart rate.Conclusion:CV3 has obvious antiarrhythmic effects on experimental arrhythmia.The mechanism of these effects is probably related to the arrest of the intraflow of Na+,Ca2+ in the cardiac cells and the depression of their cardiac autorrhythmicity and conductivity.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1998年第8期495-497,共3页
China Journal of Chinese Materia Medica
基金
国家中医药管理局课题
关键词
大果木姜子油
抗心律失常
Cinnamomum migao
antiarrtythmic effect