大果木姜子油抗实验性心律失常作用

Observation of Antiarrhythmic Effects of Cinnamomummigao H.W.Li on Experimental Arrhythmia

目的：观察大果木姜子油（ＣＶ３）抗实验性心律失常作用。方法：采用氯仿、肾上腺素（Ａｄｒ）、毒毛旋花子甙Ｋ（毒Ｋ）、氯化钡（ＢａＣｌ２）建立小鼠、家兔、豚鼠、大鼠心律失常模型，随机分对照组、ＣＶ３组、慢心律组（ＭＸＬ），观察各组对抗心律失常作用。结果：ＣＶ３组能显著降低氯仿致小鼠室颤发生率；推迟及缩短Ａｄｒ致家兔心律失常发生时间及持续时间，提高毒Ｋ致豚鼠心律失常剂量；降低ＢａＣｌ２致大鼠各类心律失常发生率及各类型评分，减慢心率。结论：ＣＶ３具有对抗实验性心律失常作用。作用机理与ＣＶ３阻止心肌细胞膜Ｎａ＋，Ｃａ２＋内流、降低其自律性。

Objective:To investigate the effects of Cinnamomum migao on experimental arrhythmia.Method:Arrhythmic models of mice,rabbits,guinea pigs and rats were built using chloroform(Chl),adrenalin(Adr),strophanthinK (SptK)and barium chloride (BaCl2).The affected animals were divided randomly into three groups: control group,Cinnamomum migao (CV3)group and mexiletine (MXL)group,so as to observe and compare the antiarrhythmic effects.Result:CV3 could reduce the incidence of venticular fibrillation caused by ch1 in mice and the ventricular tachycardia induced by Adr in rabbits, delay the onset time of this arrhythmia.increase the arrhythmic doses of SptK in guinea pigs,reduce the incidence of some arrhythmia caused by BaCl2 in rats and slow down their heart rate.Conclusion:CV3 has obvious antiarrhythmic effects on experimental arrhythmia.The mechanism of these effects is probably related to the arrest of the intraflow of Na+,Ca2+ in the cardiac cells and the depression of their cardiac autorrhythmicity and conductivity.