心肌缺血预适应对老年急性心肌梗死患者近期病死率的影响

The pre-adaptation influence of myocardial ischemia on near-term mortality rate of acute myocardial infarction elderly

目的探讨心肌缺血预适应对老年急性心肌梗死（AMI）患者近期病死率的影响．方法对照分析33例有心肌缺血预适应老年AMI患者（A组）与22例无心肌缺血预适应老年AMI患者（B组）的临床资料。结果A组肌酸磷酸激酶（CPK）与肌酸磷酸激酶同功酶MB（CK-MB）峰值、泵功能障碍发生率及近期死亡率均显著低于B组（P＜0．05～0．01）。结论CPK与CK-MB峰值的降低，提示心肌缺血预适应有缩小心肌梗死范围的作用；由于梗死范围缩小，故泵功能障碍发生率降低，这是使有心肌缺血预适应老年AMI患者近期病死率降低的主要原因。

Objective Influence on near-term mortality rate by ischemic pre-adaptation in aged patients with acute myocardial infarction(AM) was studied. Methods The clinical data of 33 elderly AMI patients by ischendc pre-adaptation(group A) and 22 elderly patients without pre-adaptation(group B) were compared. Results Peak level of serum CPK and CPK-MB;incidence of cardiac pump function disturbance and near-term mortality rate in group A were significantly lower than that in the group B(P<0.05~0. 01). beclusions It is suggested that the infarct size was liwhted by pre-adaptation. The incidence of cardiac pumP function disturbance was reduced and the near-term mortality rate decreased.