健康生活方式对短暂性脑缺血发作患者预后的影响

Effect of healthy life style on prognosis of patients with transient ischemic attack and its mechanism

目的探讨健康生活方式对短暂性脑缺血发作(TIA)患者预后的影响及其机制。方法选择65例TIA患者作为治疗组,对其进行健康生活方式指导,确保其能坚持健康生活方式,按1∶1配对原则回顾性选择未建立健康生活方式的65例TIA患者作为对照组,2组均使用阿司匹林肠溶片、曲克芦丁片等常规治疗,治疗6个月。治疗前后进行血液流变学特性、血脂及血同型半胱氨酸水平检测,调查比较6个月内2组患者不良临床事件的发生率。结果治疗组血液流变学特性明显改善,与对照组比较差异有统计学意义(P<0.05);血清胆固醇、低密度脂蛋白、甘油三酯和血浆同型半胱氨酸水平与对照组比较明显下降(P<0.05);治疗组不良事件发生率(10.8%)较对照组(35.4%)亦显著下降(P<0.05)。结论长期坚持健康生活方式能有效控制高血脂、高同型半胱氨酸血症等危险因素,进而改善TIA患者的长期预后。

Objective To investigate the effect of healthy life style on the prognosis of patients with transient ischemie attack （TIA）. Methods Sixty-five patients with TIA were selected as treatment group and instructed to develop healthy life style. According to 1 ,＂ 1 match principle, 65 TIA patients not developing healthy life style were retrospectively selected as control group. Meanwhile, both groups were treated with Aspirin and Troxerutin tablets, etc. for 6 months. We detected characteristics of hemorheology and the level of blood lipid and homocysteine before and after treatment, and compared the incidenee rates of bad clinical events in treatment group with that in control group within 6 months. Results Six months after treatment, compared with that of the patients in control group, the eharaeteristics of hemorheology of the patients in treatment group was significantly ameliorated（P〈0.05）and the levels of serum cholesterol, low density lipoprotein, triglyceride and homoeysteine decreased significantly（P〈0.05）. There was also a significant difference in the incidence rates of bad clinical events between treatment group （10.8%） and control group （35.4%）（P〈0.05）. Conclusion The prognosis of the patients with TIA can be improved through developing healthy life style for a longer time and its mechanism may be through decreasing the risk factors, such as hyperlipemia, high homocysteine, etc.