依达拉奉联合降纤酶治疗脑梗死临床疗效观察

Observation on therapeutic efficacy of edaravone-defibrase combination on acute cerebral infarction

目的观察依达拉奉联合降纤酶治疗急性脑梗死的临床效果及安全性。方法90例急性脑梗死患者随机分为2组,分别采用降纤酶及依达拉奉联合降纤酶治疗,以疗程3d、7d、14d神经功能缺损程度评分观察疗效。结果2组病人疗程3d、7d、14d神经功能缺损程度评分及疗效差异有统计学意义。结论依达拉奉联合降纤酶治疗急性脑梗死安全有效。

Objective To investigate the therapeutic efficacy and the safety of edaravone-defibrase combination on acute cerebral infarction. Methods Ninty patients with acute cerebral infarction were enrolled into the study and randomly divided into 2 groups. The patients in experimental group （n=48）were treated with the edaravone-defibrase combination, and patients in control group （n=42）were treated only with defibrase. The therapeutic efficacy and points included Chinese stroke neurological functional deficit scale at 3d, 7d, 14d. Results The neurological functional deficits had more improvement in experimental group than that in control group at 3d, 7d, 14d. Conclusion The edaravone-defib rase combination is effective to improve the neurological function and ability of daily living for acute cerebral infarction.