长期硬膜外吗啡复合去炎松治疗癌痛及药代动力学研究

Epidural triamcinolone in relieving long-term advanced cancer pain combined with morphine and it's pharmacokinetic study

目的:观察硬膜外腔(ES)注射吗啡(M)复合去炎松A(TA)治疗癌痛作用和TA药代动力学研究。方法:观察104例ES注射M复合TA的癌痛病人,高效液相色谱法检测8例TA血药浓度后行药代动力学研究。结果:每日注射M3.84±3.94mg;副反应率7.69%;平均视觉模拟评分(VAS)3.16±2.83分,TA平均消除半衰期(t_(1/2))1.63±0.36/d,平均累积系数(R)1.06±0.04μg/ml。结论:长期间断ES注射tA可增强M镇痛效果,未形成血中TA蓄积。

To investigate epidural morphine(M) combined with triamcinolone A(TA) for advanced cancer pain and to study pharmacokineties of TA. Method.. TA 40mg/w was epidually combined with M3.84±3.94mg/d in 104 advanced cancer patients and TA blood concentration was measured with high performance liquid chromatography. Result: The rate of adverse reaction was 7.69% and visual analog scale was 3.16±2.83. The plasma elimination half life (t_(1/2)) was 1.63±0.36d; plasma accumulation coefficient (R) was 1.06-1-0.04μg/ml. Conclusion: The analgesic effect of M is potentiated by TA and there is no TA accumulation in plasma following long-term epidural administration.