摘要
目的探讨人工流术中不同给药方法的丙泊酚用量、麻醉效果、镇痛效果、术中生命体征的变化及清醒恢复时间。方法选择门诊ASAⅠ～Ⅱ级早孕自愿无痛人流患者120例,随机分为丙泊酚加雷米芬太尼组(A组)和丙泊酚加芬太尼组(B组)。A组静脉注射雷米芬太尼0.5μg/kg,继之缓慢静脉注射丙泊酚1.5mg/kg;B组静脉注射芬太尼1μg/kg,丙泊酚用法同A组。结果A组术后2min SpO2下降明显(P<0.05);两组术后2min与术前的SBP、DBP、HR比较有显著性差异(P<0.05);手术结束与术前的比较无显著性差异(P>0.05);组间同一时点比较无显著性差异(P>0.05)。两组麻醉效果、镇痛效果相比,未见明显差异(P>0.05)。A、B两组患者术中丙泊酚总量分别为(2.55±0.65)和(3.46±0.93)mg/kg,组间比较有显著性差异(P<0.05)。A组和B组清醒时间分别为(6.85±1.08)和(7.60±1.60)min,组间比较有显著性差异(P<0.05)。患者离院时间,A组为(13.5±2.1)min,B组为(20.3±2.5)min,组间比较有显著性差异(P<0.05)。结论两种配伍方法各有利弊,在临床实践中根据情况选择。
Objective To compare the dosage of propofol, anesthesia effect, analgesic effect and the variation of sign in operation and the time of resuscitation in different complicated administrations of propofol. Methods One hundred-twenty ASA Ⅰ-Ⅱ outpatients in premature pregnancy expected to have analgesic abortion were randomly divided into two groups of 60 each： group A received remifentanyl 0.5μg/kg by vein injection, then slowly inject propofol 1.5 mg/kg; group B received fentanyl 1μg/kg, and the same administration of propofol. Results There was significant decrease of SpO2 in two minute after operation in group A （P〈0.05）; There were significant difference between two minute after operation and baseline in SBP. DBP. HR in the two group respectively （P〈0.05）. There was no significant difference in all indexes between the termination of the operation and the baseline and between two groups at the same time point （P〉0.05）. Compared group B, there was also no significant difference in anesthesia effect and analgesic effect （P〉0.05）, but there were significant difference in dosage of propofol and the time of resuscitation （P〈0.05）. Conclusion The two administrations both have its advantage and detriment, we should chose better one according to the clinic situation.
出处
《中国医药指南》
2009年第16期42-43,共2页
Guide of China Medicine
