注射用尤瑞克林对急性缺血性卒中患者脑血流储备能力的影响

Effect of Urinary Kallidinogenase Injection on Cerebrovascular Reserve Capacity in Patients with Ischemic Stroke

目的 观察注射用尤瑞克林对缺血性卒中患者脑血流储备能力的影响。 方法 选择大脑中动脉区域梗死的急性缺血性卒中患者154例，随机分为两组：治疗组76例，给予注射用尤瑞克林0．15PNA，同时给予缺血性卒中的基础治疗；对照组78例，给予相同缺血性卒中的基础用药上，给予生理盐水静脉注射。利用经颅多普勒技术对急性缺血性卒中患者进行CO2吸入试验，观察使用注射用尤瑞克林治疗前后的脑血流储备能力。 结果 治疗组和对照组患者在治疗后10d神经功能缺损程度均有不同程度改善，而治疗组患者在治疗后10d脑血流储备能力较对照组有明显改善。 结论 注射用尤瑞克林可能有助于改善缺血性卒中患者的脑血流储备能力。

Objective To observe the influences of Urinary Kallidinogenase injection in patients with ischemic stoke. Methods 154 patients with middle cerebral artery territory stroke were included in this trial and all patients were randomly divided into two groups. 76 patients in treatment group were treated with Urinary Kallidinogenase injection and basic therapy for 10 days after inclusion, while control group were treated with physiological saline and basic therapy. We performed 5% CO2 inhalation test to evaluate the cerebrovascular reserve（CVR）, for all patients pre and post therapy using transcranial Doppler ultrasound. Results Function impairment of all patients had different degree of improvement. Patients treated with Urinary Kallidinogenase injection appeared obvious improvement than control group. Conclusion Urinary Kallidinogenase injection may improve the CVR in patients with ischemic stroke.