摘要
血管性痴呆与阿尔茨海默病、混合性痴呆的鉴别诊断面临困难。目前应用的血管性痴呆临床诊断标准的敏感度和特异度偏低。近年一些生物学标记物作为病理生理过程的客观指标被应用于与血管性痴呆的诊断和鉴别诊断。这些生物学标记物包括结构影像学、正电子发射断层扫描（positron emission tomography，PET）、脑脊液标记物[淀粉样β多肽（Amyloid β-peptide，Aβ）和tau蛋白]、血浆细胞因子和脑血管血液动力学检查等。初步的研究结果提示脑脊液Aβ和脑的脱氧葡萄糖-PET显像对于血管性痴呆的诊断和鉴别诊断具有较高的应用价值。
The differential diagnosis between vascular dementia（VaD） and Alzheimer＇s disease（AD） or mixed dementia（MD） is not always easy in clinical practice. The most widely used diagnostic criteria for VaD are not specific and sensitive enough. Some candidate biomarkers have been evaluated in the discrimination between VD and AD or MD. These biomarkers include magnetic resonance tomography, emission tomography, cerebrospinal fluid markers, plasma cytokines profile and cerebral haemodynamics. The cerebrospinal fluid（CSF） biomarkers amyloid peptide 1-42 （A beta 42） and FDG-PET may be valuable tool to discriminate VD vs. AD patients and possibly improve diagnostic accuracy.
出处
《中国卒中杂志》
2009年第7期601-606,共6页
Chinese Journal of Stroke
关键词
痴呆
血管性
生物学标记
诊断
Dementia, vascular
Biological markers
Diagnosis
