骆驼蓬总碱的毒性

STUDY ON THE TOXICITY OF TOTAL ALKALOID OF PEGANUM HARMALA

目的：研究骆驼蓬总碱的毒性。方法：用骆驼蓬总硷对小鼠进行急性毒性，大鼠进行亚急性毒性实验。结果：小鼠急性毒性实验测出骆驼蓬总硷，于腹腔、静脉注射及灌胃３种给药途径１次给药的ＬＤ５０，以及可信限分别为：１４４ｍｇ／ｋｇ（１３１．７～１５７．９ｍｇ／ｋｇ）、５６ｍｇ／ｋｇ（４８．３～６４．９ｍｇ／ｋｇ）、２８９ｍｇ／ｋｇ（２１８．５～３８２．３ｍｇ／ｋｇ）。在大鼠亚急性毒性实验可见３００ｍｇ／ｋｇ骆驼蓬总碱引起肾病变和尿素氮升高，停药后肾毒性程度可降低。结论：骆驼蓬总碱毒性的靶器官是肾脏，在停药之后肾脏病变在一定程度上是可逆的。

Objective: To study toxicity of total alkaloid of Peganum harmala(TAH). Methods: Mice and rats were used for detecting acute and subacute toxicity of TAH. Results: In mice LD_50 and 95% confident limit of TAH by i.p, i.v and p.o administration were 144mg/kg(131.7～157.9mg/kg), 56mg/kg(48.3～64.9mg/kg) and 289mg/kg(218.5～382.3mg/kg) respectively. Subancute toxicity test in rats showed that 300mg/kg of TAH can induce renal pathological change and higher BUN level, the degree of nephro-toxicity can reduce after stopping administration. Conclusion: Kidney is the toxic target organ of TAH, to some degree the nephro-toxicity can reverse after stopping administration.