摘要
目的：比较替尼泊甙（ＶＭ２６）和卡氮芥（ＢＣＮＵ）分别联合口服环己亚硝脲（ＣＣＮＵ）治疗脑胶质瘤的疗效。方法：对２７例脑胶质瘤手术切除后，采用微导管进行超选择脑动脉灌注法分组灌注ＶＭ２６（Ａ组）和ＢＣＮＵ（Ｂ组），并且两者联合口服ＣＣＮＵ，化疗后，依肿瘤实际体积的变化和平均生存时间观察疗效。结果：Ａ组有效率１２／１５，Ｂ组有效率４／１２，Ａ组和Ｂ组平均生存时间分别为２５．３个月和２１．１个月（Ｐ＜０．０５）。结论：超选择脑动脉灌注ＶＭ２６联合口服ＣＣＮＵ治疗脑胶质瘤疗效高，毒副作用小。
Objective: To compare the therapeutic effects of VM26 (group A) with BCNU (group B) on brain glioma. Methods: 27 of patients with brain glioma were treated differently with microtube by superselective intracerebral arterial infusion of VM26 and BCNU atfer the operation, CCNU was given orally in both groups. The therapeutic effects were evaluated by the tumor sizes and the mean survival time after chemotherapy. Results: The effective proportion of group A and group B were 12/15 and 4/12 separately. The mean survival time of group A and group B were 25.3 months and 21.1 months separetely (P<0.05). Conclusion: The therapeutic effects of VM26 given by superselective intracerebral arterial infusion and CCNU taken orally were better and less toxiciting or side effect.
出处
《中山医科大学学报》
CSCD
1998年第3期217-219,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省科委及中山三院基金
关键词
神经胶质瘤
替尼泊甙
卡氮芥
灌注
脑肿瘤
glioma/therapy
teniposide/therapeutic use
carmustine/therapeutic use
lomustine/therapeutic use
perfusion, regional
