维生素K对肾结石患者尿抑制作用的影响

Vitamine K and urine inhibitory ability against urolithiasis in patients with nephrolithiasis

为了解维生素Ｋ在尿石形成中作用，用超滤法分离正常人和草酸钙肾结石患者尿中大分子物；结合草酸耐受试验，检测肾结石患者应用维生素Ｋ前后尿不同分子量物质的草酸耐受量。结果：正常人及肾结石患者尿分子量１００００～３００００大分子物草酸耐受量最高；肾结石患者较正常人草酸耐受量低（分别为２．７２±０．７４ｍｌ和３．７５±０．３５ｍｌ，Ｐ＜０．０５）；肾结石患者应用维生素Ｋ后尿１００００～３００００大分子物草酸耐受量增加（３．１９±０．５７ｍｌ，Ｐ＜０．０５）。提示尿中草酸钙结石抑制物主要为分子量１００００～３００００的大分子物。

Vitamine K was instituted to 12 nephrolithiasis patients for one week and urine specimens were collected both before and after the vitamine K institution.The urine specimens were superfiltrated and the inhibitory activity of substances with various molecular weight was evaluated with oxalate tolerance test (OTT).The result revealed that the oxalate tolerance was the highest with substance of 10 000～30 000 molecular weight in the urine of either normal subjects or in nephrolithiasis patients.The oxalate tolerance was lower in nephrolithiasis patients than in the normal subjects (P<0.05).Significant increase of oxalate tolerance of urine substances with a molecular weight of 10 000～30 000 has been observed when vitamine K was instituted to the nephrolithiasis patients (P<0.05).The above result suggested that the megasubstances with a molecular weight of 10 000～30 000 play the main role in inhibiting the calcium oxalate stones and vitamine K would enhance the urine inhibitory ability against nephrolithiasis.