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高糖环境下大鼠主动脉内皮细胞COX-2 mRNA表达的变化 被引量：2

Expression of COX-2 mRNA in rat aortic endothelial cells in high glucose environment
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摘要 通过SD大鼠体内和体外实验，观察主动脉内皮细胞高糖培养下及糖尿病大鼠体内其环氧化酶-2（COX-2）mRNA的表达及阿司匹林的干预作用。结果显示高糖可引起主动脉内皮细胞COX-2 mRNA表达明显增加，阿司匹林可减少其COX-2 mRNA的表达。 The expression of cyclooxy genase-2 （Cox-2） in endothelial cells （ECs） was determined. These cells were from aorta of diabetic rat and SD rats, cultured in vitro with high glucose. High glucose increased COX-2 mRNA expression both in rat aortic ECs cultured in vitro and in vivo,which was inhibited by aspirin treatment.
作者 陆颖理 叶婷婷 杨华 陈奕 余娇 赵丽娟 夏芳珍 王宁荐 施超 乔洁 叶林 林东平 吴万龄
机构地区 上海交通大学医学院附属第九人民医院内分泌代谢科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2009年第4期382-383,共2页 Chinese Journal of Endocrinology and Metabolism
基金 上海市科委重点基金（07JC14042）
关键词 主动脉 内皮细胞 高糖 COX-2 阿司匹林 Aorta Endothelial cells High glucose COX-2 Aspirin
分类号 R686 [医药卫生—骨科学]
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参考文献6

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共引文献7

同被引文献22

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中华内分泌代谢杂志
2009年 第4期

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