甲状腺^18F-FDG弥漫性摄取增高的临床意义

Clinical significance of diffusely increased ^18F-FDG uptake in the thyroid

回顾性分析瑞金医院核医学科2007年6月至2008年1月1 190例^18氟-脱氧葡萄糖（^18F-FDG）PET／CT检查者，发现20例（1．63％）甲状腺^18F-FDG弥漫性摄取增高者，女性检出率明显高于男性（3．0％vs0．63％），其甲状腺球蛋白抗体（TgAb）、甲状腺微粒体抗体（McAb）阳性检出率显著高于甲状腺不摄取^18F—FDG者（55％vs10％）。其中11例抗甲状腺抗体阳性者甲状腺^18F-FDG摄取的SUVmax与TgAb、McAb水平无相关性（均P〉0．05）。甲状腺^18F—FOG摄取增高者其抗甲状腺抗体阳性检出率增高，可能与桥本甲状腺炎有关。

Total 1 190 subjects undertook ^18F-FDG PET/CT from June 2007 to January 2008 in the nuclear medicine department of Ruijin hospital, and the data were retrospectively reviewed. 20 （ 1.6% ） subjects were found to have increased diffuse ^18F-FDG uptake in the thyroid. The detectable rate in female was higher than that in male（3.0% vs 0. 63% ）. Compared with the control subjects without ^18F-FDG uptake,the positive rates of thyroid globulin antibody （TgAb）,thyroid mierosome antibody（McAb） in the study group were obviously higher （55%vs 10% ）. The TgAb and McAb levels were not correlated with SUVmax of ^18F-FDG uptake in ll subjects with positive anti-thyroid antibody（ all P〉0.05 ）. Diffuse increase of ^18F-FDG uptake in the thyroid seems to be linked with chronic lymphocytic thyroiditis.