骨形态蛋白在脊柱外科应用的最新进展

Latest application of bone morphogenetic protein

骨形态发生蛋白(bone morphogenetic proteins,BMPs)不仅能够诱导异位骨化,而且能够作用于成骨细胞和骨祖细胞,提高其成骨分化的能力。在骨的形成及骨折愈合过程中发挥作用,尽管BMPs在矫形外科中的应用仍处于初期阶段,但是其发展前景极其广阔,了解植骨融合的确切机制具有重要的意义。

BMPs （bone morphogenetic proteins. ） were first identified as proteins that were able to induce eetopic osteogenesis and were shown to enhance the osteogenic differentiation of both osteoblast - like and osteoprogenitor cells. Clearly the use of BMPs in orthopaedics is still in its formative stage, but the data suggest an exciting and promising future for the development of new therapeutic applications. Identification of a precise mechanism for the factors in the progression may be helpful for clinical treatments.