粗针皮下透刺神道穴对慢性荨麻疹患者症状积分及血清IgE的影响

Influence of Penetrative Needling of Shendao(GV 11) on the Symptom Score and Serum IgE Content in Chronic Urticaria Patients

目的:观察粗针皮下透刺神道穴对慢性荨麻疹患者的疗效。方法:将60例慢性荨麻疹患者随机分为粗针组及西药组,各30例。粗针组采用粗针皮下透刺神道穴,每日1次,每周5次,治疗2周为一疗程。西药组口服盐酸左西替利嗪片,5mg/次,6周为一疗程。观察两组患者治疗前,治疗2周、6周、12周的血清IgE水平及症状积分的变化。结果:两组患者在治疗2周、6周血清IgE水平与治疗前比较均下降,差异有统计学意义(P<0.01):治疗12周后,粗针组血清IgE水平和症状积分与治疗前比较仍下降(P<0.01),西药组血清IgE水平和症状积分与治疗前比较虽有下降,但差异无统计学意义(P>0.05);治疗前、治疗2周、6周两组患者间的血清IgE水平和症状积分比较差异没有统计学意义(均P>0.05);治疗12周,粗针组血清IgE水平和症状积分明显低于西药组(P<0.05);两组治疗前后血清IgE水平和症状积分呈正相关。结论:粗针皮下透刺神道穴可以有效降低慢性荨麻疹患者的血清IgE水平及改善临床症状。

Objective To observe the changes of symptom scores and serum IgE level after treatment with thick-needle subcutaneous penetration of Shendao （GV 11 ） in chronic urticaria patients. Methods A total of 60 chronic urticaria patients were randomly divided into acupuncture group （n = 30） and medication group （n = 30）. Subcutaneous penetrative needling was applied to GV 11 with thick acupuncture needle （retained for 4 h/time, once daily, 5 times/week） for patients of acupuncture group and Levocetirizine Hydrochloride tablets （5 mg/time, once daily in the first two weeks, then, once every other day in the 3rd and 4th weeks, and once every 3 days in the last two weeks） were given to patients of medication group. Serum IgE content was assayed before and 2,6,12 weeks after the treatment by chemiluminescent technique. Symptom scores were obtained by ＂0-3 four levels assessment＂ method in the light of the size of the wheal and the itching severity. Results Self-comparison in- dicated that the symptom scores and serum IgE levels declined significantly （P〈0.01） 2 and 6 weeks （Wks） after the treatment in both acupuncture and medication groups,and 12 Wks after the treatment in the acupuncture group （P〈0.01）. Comparison be- tween two groups showed that the symptom score and serum IgE content of acupuncture group were significant lower than those of medication group 12 Wks after the treatment （P〈~0.05）. No significant differences were found between two groups in the symp- tom scores and serum IgE levels before, 2 and 6 Wks after the treatment （P^0.05）. A positive correlation exists between the symptom score and the serum IgE level before and after the treatment in both groups. Conclusion Thick-needle subcutaneous penetration of Shendao （GV 11 ） can effectively improve clinical symptoms of chronic urticaria patients, which may be closely re- lated to its effect in lowering peripheral blood IgE level.