穴位贴敷治疗支气管哮喘:多中心随机对照研究

Acupoint sticking therapy for treatment of bronchial asthma:a multicenter controlled randomized clinical trial

目的:观察穴位敷贴对支气管哮喘患者临床症状、生活质量的影响。方法:采用多中心、随机、双盲试验方法,将188例患者分为药物贴敷组(125例)及安慰组(63例)。两组均取大椎、肺俞、天突等穴,药物贴敷组贴敷胡椒、白芥子、细辛等中药研磨混合姜油及姜汁制成的药饼;安慰组贴敷红米、黑米、玉米混合少量姜汁制成的圆饼。观察两组患者在生活质量评分(AQLQ),日间、夜间症状评分及自我疗效评分、肺功能值方面的变化。结果:药物贴敷组在AQLQ量表中日常行为、环境因素、AQLQ总计分值及日间症状、自我疗效评分方面较安慰组明显改善(均P<0.05)。两组患者肺功能1秒钟用力呼气容积(FEV1)及1秒钟用力呼气容积占预计值百分比(FEV1/FVC)无明显差异(均P>0.05)。结论:穴位敷贴对支气管哮喘患者临床症状改善显著,并能提高患者的生活质量。

Objective To observe the effect of acupoint sticking on clinical symptoms and life quality in patients with bronchial asthma. Methods Multicenter randomized double-blind clinical trial was done, one hundred and eighty-eight cases were divided into a medication acupoint sticking group （125 cases） and a placebo group （63 cases）. Dazhui （GV 14）, Feishu （BL 13）, Tiantu （CV22）, etc. were selected in both groups. The medication cakes were made of grinding pepper, brassica atba seeds, asarum, etc. into fine powder mixed with ginger oil and ginger juice, applied on acupoints in the acupoint sticking group. While another compound cakes made of powder of red rice, black rice, maize mixed with small amount of ginger juice, were used in the placebo group. Asthma Quality of Life Questionnaire（AQLQ）, symptom scores during the day and night, scores of self effect, and the value of lung function were observed. Results The value of daily behavior and environmental factors of AQLQ, total scores of AQLQ, daytime symptoms and scores of self effect in the medication acupoint sticking group, were significantly im- proved compared to those of placebo group （all P〈0.05）. The lung function of forced expiratory volume in one second （FEV1） and the percentage of forced expiratory volume in one second in predicted value （FEV1/FVC） had no significant diffrence between two groups （both P〉0.05）. Conclusion The acupoint sticking therapy can significantly improve clinical symptoms of patients with bronchial asthma, and can improve life quality of the patients.