针刺治疗非酒精性脂肪性肝炎疗效观察

Observation on therapeutic effect of acupuncture for treatment of patients with nonalcoholic steatohepatitis

目的:观察针刺治疗非酒精性脂肪性肝炎的临床疗效。方法:将98例患者随机分为针刺组(50例)和药物组(48例)。针刺组针刺肾俞、关元、太溪、三阴交等穴,每周3次;药物组口服多烯磷酯酰胆碱胶囊,每日3次,两组均治疗12周。比较两组治疗前后临床症状、血清酶学、血脂及腹部CT的变化。结果:针刺组及药物组治疗后丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)及γ-谷氨酞转移酶(GGT)较治疗前明显下降(均P<0.01),针刺组治疗后甘油三酯(TG)及总胆固醇(TC)较治疗前下降(均P<0.01),药物组治疗后TG及TC与治疗前比较,差异无统计学意义(均P>0.05);针刺组治疗后ALT、AST、GGT、TG及TC较药物组均下降更明显(均P<0.01)。治疗后经CT检查显示两组非酒精性脂肪肝的程度均较治疗前有明显的改善(均P<0.01),且针刺组改善优于药物组(P<0.01)。结论:针刺治疗非酒精性脂肪性肝炎疗效显著。

Objective To observe the therapeutic effect of acupuncture for treatment of patients with nonalcoholic steatohepatitis. Methods Ninety-eight cases were randomly divided into an acupuncture group （n=50） and a medi cine group （n=48）. The acupuncture group was treated with acupuncture at Shenshu （BL 23）, Guanyuan （CV 4）, Taixi （KI3）, Sanyinjiao （SP 6）, etc. ; the medicine group was treated with oral administration of Polyene Phosphatidylcholine Capsules. They were treated for 12 weeks. The changes of clinical symptoms, serum enzyme, blood fat and abdominal CT performance were compared between the two groups before and after treatment. Results After treatment, alanine aminotransferase （ALT）, aspartate aminotransferase fAST）, galactosylhydroxylysyl glucosyl transferase （GGT）, triglyeride （TG） and total cholesterol （TC） significantly decreased in the acupuncture group （all P〈0. 01） ; ALT, AST and GGT significantly decreased in the medicine group （all P〈0.01 ）, and there were no significant differences in changes of TG and TC in the medicine group （both P〉0.05）. After treatment, CT image showed there was significant improvement of liver injury in both groups （both P〉0.01）, and the improvement of liver injury in the acupuncture group was superior to that in the medicine group （P〈0.01）. Conclusion Acupuncture has a significant therapeutic effect on nonalcoholic steatohepatitis.