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认知任务的功能磁共振技术在神经药理学研究中的进展 被引量：1

Current advance in neuropharmacology by functional magnetic resonance imaging during cognitive tasks
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摘要 功能核磁共振技术的飞速发展,使药物作用前后神经元的活动状况能够通过脑血氧含量变化间接反映出来。这使得药理学家可以借助核磁共振技术,评价药物对脑区和网络空间的作用。目前,应用于人类受试者的神经药理学磁共振研究涉及的药物,主要集中在单胺能与胆碱能神经传递的激动剂与抑制剂方面。该文主要介绍药物磁共振成像(phMRI)的基本概念和实验中常用的任务,同时结合多巴胺能药物的研究,综述了phMRI的最新研究进展。 The rapid development of functional magnetic resonance imaging allows pharmacologists to indirectly map neuronal activations imposed by drugs through the cerebral blood oxygenation level change and assess the effects of drugs in brain regions and network. Currently, human neuropharmacological magnetic resonance imaging researches mainly focus on agonists and antagonists of monoaminergic and cholinergic neurotransmissions. This article introduces some basic notions and experiment designs on pharmacological magnetic resonance imaging, and reviews a lot of latest researches in this field.
作者 吴润果 邱蕾 郑璐 张占军 罗跃嘉 王永炎
机构地区 北京师范大学认知神经科学与学习国家重点实验室 中国中医科学院临床与基础研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第8期984-987,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30873458) 北京市自然科学基金资助项目(No7082050) 全国优秀博士论文专项基金资助项目(No2007B7) 高等学校博士学科点专项基金资助项目(No200800271014) 北京市新医药学科群项目资助项目(No100270569)
关键词 神经药理 功能磁共振 认知 血氧水平依赖 多巴胺 neuropharmacology, fMRI, cognition BOLD dopamine
分类号 R-05 [医药卫生] R338.64 [医药卫生—人体生理学]
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参考文献31

  • 1胡小平.功能磁共振成像[M]//罗跃嘉.认知神经科学教程.北京:北京大学出版社,2006:95-108.
  • 2Ogawa S, Lee T M, Kay A R, et al. Brain magnetic-resonance-imaging with contrast dependent on blood oxygenation [ J ]. Proc Natl Acad Sci USA, 1990, 87(24) :9868 -72.
  • 3Ogawa S, Tank D W, Menon R, et al. Intrinsic signal changes accompanying sensory stimulation:functional brain mapping with magnetic Resonance imaging [ J ]. Proc Natl Acad Sci USA, 1992, 89(13) :5951 -5.
  • 4王小姗,狄晴,曹辉,张颖冬,王伟.海风藤酮治疗脑梗死的活体磁共振成像与波谱研究[J].中国药理学通报,2005,21(11):1324-1327. 被引量：2
  • 5Marsden C A, Shah Y, Steward C, et al. Issues in human pharmacological MRI[ J]. Behav Pharmoacol, 2005, 16 : S1 - S1.
  • 6Honey G, Bullmore E. Human pharmacological MRI [ J ]. Trends Pharmacol Sci, 2004, 25 (7) : 366 - 74.
  • 7Thomoson, Web of science[ DB] ISI Web of knowledge,2009 ,http ://www. isi knowledge, com.
  • 8吴义根,赵小虎,郭胜利.核磁共振脑功能成像BOLD信号的特征及其神经电生理机制[J].自然科学进展,2007,17(1):11-18. 被引量：2
  • 9Gordon G R J, Choi H B, Rungta R L, et al. Brain metabolism dictates the polarity of astrocyte control over arterioles [ J ]. Nature, 2008, 456(7223):745 -U745.
  • 10Wager T D, Rilling J K, Smith E E, et al. Placebo-induced changes in fMRI in the anticipation and experience of pain [ J ]. Science, 2004, 303(5661 ) :1162 -7.

二级参考文献75

  • 1赵小虎,王培军,唐孝威.静息状态脑活动及其脑功能成像[J].自然科学进展,2005,15(10):1160-1166. 被引量：19
  • 2王伟,董为伟.海风藤酮对缺血鼠脑磷脂酶A_2、三磷酸肌醇及自由基形成的影响[J].中华神经科杂志,1996,29(6):325-328. 被引量：23
  • 3Muller TB, Haraldseth O, Jones RA et al. Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion[J]. Stroke,1995,26:451-8.
  • 4Urenjak J,Williams S R,Gadian G D et al. Specific expression of N-acetyl aspertate in neurons,olegodendrocytes in vitro[J]. Neurochem,1992,59:55-61.
  • 5Barker PB, Gillard JH, van Zijl PC et al. Acute stroke: evaluation with serial proton MR spectroscopy findings[J]. Stroke,1995,26:225-9.
  • 6Andrew ER. Imaging: A historical overview[M].In:Grant DW, Harris RK, Chichester, ed. Encyclopedia of nuclear magnetic resonance. New York: John Wiley,1996,2462-72.
  • 7Henriksen O.MR spectroscopy in clinical research[J]. Acta Radiol, 1994,35(2):96-116.
  • 8Longa EZ,Weinstein PR, Carlsons S et al.Reversible middle cerebral artery occlusion without crainectomy in rats[J]. Stroke, 1989,20:84-91.
  • 9Feuerstein G,Yue TL,Lysko PG.Platelet activating factor, A putative mediator in central nervous system injure[J]. Stroke,1990,21(11):90-4.
  • 10Hinrichs H, Scholz M, Tempelmann C, et al. Deconvolution ofevent-related fMRI responses in fast-rate experimental designs:tracking amplitude variations. J Cognitive Neurosci, 2000,12 (Suppl 2): 76-89.

共引文献2

同被引文献29

  • 1Czobor P,Skolnick P,Beer B,Lippa A.A multicenter,placebo-controlled,double-blind randomized study of efficacy,and safety of ocinaplon(DOV 273,547)in generalized anxiety disorder[J].CNS Neurosci Ther,2010,16(2):63-75.
  • 2Olsen R W,Sieghart W.GABAA receptors:Subtypes provide diversity of function and pharmacology[J].Neuropharmacology,2009,56(1):141-8.
  • 3Low K,Crestani F,Keist R,et al.Molecular and neuronal substrate for the selective attenuation of anxiety[J].Science,2000,290(5489):131-4.
  • 4Atack J R,Wafford K,Tye S J,et al.TPA023,an agonist selective for α2-and α3-containing GABAA receptors,is a nonsedating anxiolytic in rodents and primates[J].J Pharm Exp Ther,2006,316(1):410-22.
  • 5Nehrenberg D L,Rodriguiz R M,Cyr M,et al.An anxiety-like phenotype in mice selectively bred for aggression[J].Behav Brain Res,2009,201(1):179-91.
  • 6M(o)hler H.Role of GABAA receptors in cognition[J].Biochem Soc Trans,2009,37(Pt 6):1328-33.
  • 7Taliani S,Cosimelli B,Da Settimo F,et al.Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A(GABAA)alpha2 benzodiazepine receptor[J].J Med Chem,2009,52(12):3723-34.
  • 8Mirza N R,Larsen J S,Mathiasen C,et al.NS11394[3′-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl] -biphenyl-2-carbonitrile] ,a unique subtype-selective GABAA receptor positive allosteric modulator:in vitro actions,pharmacokinetic properties and in vivo anxiolytic efficacy[J].J Pharmacol Exp Ther,2008,327(3):954-68.
  • 9Atack J,Wafford K A,Street L J,et al.MRK-409(MK-0343),a GABAA receptor subtype-selective partial agonist,is a non-sedating anxiolytic in preclinical species but causes sedation in humans[J].J Psychopharmacol,in press.
  • 10Atack J,Hallett D J,Tye S,et al.Preclinical and clinical pharmacology of TPA023B,a GABAA receptor α2/α3 subtype-selective partial agonis[J].J Psychopharmacol,in press.

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中国药理学通报
2009年 第8期

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