摘要
近年来,蛋白质组学技术飞速发展,尤其在药物的靶点确认、药物作用机制等研究中,发挥出了其极大的技术优势,明显地提高了药物发现的效率。该文对蛋白质组学的基本方法、新技术以及它在药物靶点的发现和确认、阐明药物作用机制、药物毒理学、耐药相关机制研究、临床医药研究等方面的应用进行综述。
Recently, the techniques for proteomics have made remarkable progress. They are widely used in various fields of life sciences, providing strong technical supports for relevant researches. Especially, proteomics technology has made prominent contributions to drug development and mechanism studies, magnificently improving the efficiency of discovering new drugs. This paper summarizes the classical method and new technology of proteomics. Also, its applications in drug study, including targets screening, mechanism studies, drug toxicology, researches of resistance mechanisms and clinical medical studies have been reviewed.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2009年第8期988-991,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展计划(973计划)资助项目(No2004CB518902)
