利用两相Friedel-Crafts反应合成质体醌Plastoquinone-9

Synthesis of plastoquinone-9 by two-phase Friedel-Crafts reaction

以2，3-二甲基苯胺经硅胶受载氧化剂Na2CrO7-H2SO4氧化、NaBH4还原生成的2，3-二甲基-1，4苯二酚作为质体醌的合成母体，在CH3NO2-正己烷两相反应体系中，43～45qC及BF3 Et2O催化下与从烟浸膏精制的高纯茄尼醇发生Friedel-Crafts反应合成质体醌Plastoquinone-9的氢醌，再经催化量的FeCl3·6H2O存在下的空气氧化，以满意的收率及选择性合成了Plastoquinone-9．

With two- phase reactive system of CH3NO2/n- hexane, the hydroquinone of plastoquinone -9 was prepared at 43-45 ℃ by BF3 ·Et20 catalyzed Friedel -Crafts alkylation reaction of 2,3 -dimethyl - 1,4 - hydroquinone, which was synthesized from 2,3 - dimethylaniline via oxidation,reduction, and pure solanesol iso- lated from extractum tobacco. Then through a green oxidation of hydroquinone with air and a catalytic amount of FeC13 · 6H2O, plastoquinone- 9 was synthesized in good yield and high selectivity.