阿尔茨海默病患者HMG-CoA还原酶基因多态性与血脂关系的研究

Relationship between HMG-CoA recuctase gene polymorphism and lipid level in Alzheimer's disease

目的探讨3-羟-3甲基戊二酰辅酶A(HMG-CoA)还原酶基因多态性与阿尔茨海默病(AD)的关系。方法用PCR-RFLP方法分析HMG-CoA还原酶第2内含子区ScrF1酶切多态性。结果ScrF1酶切多态性基因型频率、等位基因A、a频率在组间比较差异无显著性(P>0.05),但基因型为AA的AD患者,其总胆固醇(TC)水平显著高于基因型为aa的AD患者(P<0.01)。结论HMG-CoA还原酶ScrF1酶切多态性与AD无相关性,但患者组AA基因型与TC水平密切相关。

Objective To study the association of 3-hydroxy-3-methylglutaryl coenzyme A （HMG-CoA） recuctase gene polymorphism with Alzheimer＇ s disease （AD）. Methods HMG-CoA reeuctase genotyping was performed by polymerase chain reaction-restriction fragment polymorphism. Results There was no significant difference in frequencies of allele and genotype in ScrF1 polymorphism between AD group and control group （P 〉0.05 ）. However, the level of TC in AD patients with AA genotype was higher than that of AD patients with aa genotype （ P 〈 0. 01 ）. Conclusion No direct association was found between the ScrF1 polymorphism and AD, but there was a significant correlation between the AA genotype of the HMG-CoA reductase gene and the level of TC in AD group.