氟比洛芬酯改善术后吗啡镇痛质量

Effect of Flurbiprofen Axetil on Improvement of Morphine for Postoperative Analgesia

目的：探讨氟比洛芬酯对术后病人自控静脉吗啡镇痛的节俭作用。方法：30例ASAⅠ～Ⅱ级择期手术的妇科恶性肿瘤病人，随机分成三组，术后分别分次于不同时段静注氟比洛芬酯，同时应用病人自控静脉吗啡镇痛泵镇痛。采用视觉模拟评分法（VAS）评估镇痛效果，并记录镇痛药物用量和不良反应。结果：术后24h和48h，三组间VAS评分均无显著性差异（P〉0．05）；F1与F2组的吗啡总量、PCA按压次数和有效次数与M组比较均有显著性差异（P〈0．05orP〈0．01）；恶心、呕吐、瘙痒的发生以M组为多，F1及F2组较少，头晕的发生三组间无明显差异。结论：氟比洛芬酯用于术后病人自控静脉镇痛，能够节俭吗啡的用量，减少吗啡的副作用，提高术后镇痛质量。

Objective To investigate the effect of flurbiprofen axetil on morphine-sparing in postoperative patient-controlled analgesia. Methods Thirty ASA Ⅰ～Ⅱ patients with gynecologic malignant tumor were randomly divided into three groups, flurbiprofen axetil were administrated at different time point for different times, respectively, and the postoperative patientcontrolled analgesia was given simultaneously. The analgesic effect was evaluated with visual analogue scale（ VAS）, the dosage of analgesic drug and the side effects were recorded. Results At 24 h and 48 h pestoperation, the VAS value had no significant difference in the three groups （ P 〉 0.05 ） ; the total dosage of morphine, the press time of PCA and the effective times in group F1 and group F2 were significantly different from those in group M （ P 〈 0. 05 or P 〈 0. 01 ） ; the incidence of side effects including nausea,vomiting and pruritus in group M was higher than that in group F1 and group F2 ,while the incidence of dizziness had no significant difference in the three groups. Conclusion Flurbiprofen axetil could effectively improve the postoperative patient-controlled analgesia,decrease the dosage of morphine as well as its side effects.