氯氮平所致脂肪肝的超声观察

ultrasound observation on fatty liver caused by clozapine

目的:探讨超声在诊断氯氮平所致脂肪肝中的应用价值。方法:应用超声对精神分裂症患者服用氯氮平时间长短与所致脂肪肝关系进行观察。结果:在260名服用氯氮平患者中,用药6个月被检出脂肪肝12例,其检出率为4.6%(12/260)。用药12个月时间被检出脂肪肝68例,检出率26.2%(68/260)。用药18个月时被检出脂肪肝96例,检出率36.9%(96/260),差异有统计学意义(P<0.01)。结论:脂肪肝声像图与氯氮平用药时间长短存在密切关系。超声对早发现氯氮平所致脂肪肝具有重要价值,可作为首选检查方法。

Objective：To study the diagnotic value of ultrasound to fatty liver caused by clozapine. Methods：Ultrasonographic were used to detexct fatty liver in long - term clozapine treated schizophrenia patients. Results： A total of 260 cases who had no fatty liver diseases before, after 6 months Clozapine administration, 12 cases were confirmed to have fatty on Uhrasonography The rate was 4.6%. After 12 months administration, the occurrence tate raised 26.2%. And 18 months later ,36.9% of these cases were verified to be fatty live. And there was significant difference between then（ P 〈0. 01 ）. Conclusions： There was a closer relationship between Ultrasonography - found - fatty live and the length of time of taking Clozapine. Uhrasonography has important value to the early discovery fatty liver caused by clozapine, and can be the first - line approach diagnosis fatty liver.