摘要
交感神经系统(sympathetic nervous system,SNS)是心血管神经体液调节的核心,而其释放的儿茶酚胺(catecholamines,CA)涉及许多心血管疾病。目前认为β1和β2肾上腺素能受体(adrenergic receptors,AR)介导心肌对于CA的收缩效应以及血管平滑肌的舒张反应。然而,1989年发现了第3种β-AR亚型即β3-AR的分子特征,随后在人类心脏得以克隆,这些研究改变了β-AR系统调节心脏功能的经典模式。在血管中,激动β3-AR可产生舒张效应,但目前对于β3-AR的病理生理作用尚未完全明了。本综述主要阐述β3-AR在心血管系统功能作用的分子机制,以及β3-AR在几种常见心血管疾病中的潜在作用和将其作为新的治疗靶点的药理学机制。
The sympathetic nervous system （SNS） is central for the neurohumoral regulation of the cardiovascular system and is largely involved in many cardiovascular diseases. It is classically admitted that β-adrenoeeptors（β-AR） of the β1 and β2 subtype mediate the effects of eateeholamines（CA） on the contrac- tion of eardiae muscle, and on the relaxation of vascular smooth muscle. However, the molecular characterization in 1989 of a third β-AR subtype, β3, and later its identification in human heart has changed the classically paradigm on the regulation of heart function by the β-adrenergie system. In blood vessels, β3-AR in- duced a relaxation. But at the present time, the physiological role of β3-AR is not clearly identified. Thus, the purpose of this review is to summarize the molecular evidence supporting the functional roles of β3 -AR in cardiovascular system. In addition, this review discusses the potential role of β3-AR in several cardiovascular diseases and indicates their pharmacological involvement as a new therapeutic target.
出处
《中国分子心脏病学杂志》
CAS
2009年第4期240-245,共6页
Molecular Cardiology of China
