血清sICAM-1及sVCAM-1在胰腺癌中的表达

THE EXPRESSIONS OF SICAM-1 AND SVCAM-1 IN PATIENTS WITH PANCREATIC CANCERGONG

目的探讨血清sICAM-1及sVCAM-1在胰腺癌中的表达及临床意义。方法用ELISA法测定了93例胰腺癌、42例慢性胰腺炎、51例健康人血清sICAM-1s、VCAM-1含量,并进行相关比较。结果胰腺癌患者血清sICAM-1、sVCAM-1水平明显高于慢性胰腺炎及健康对照组(P<0.01);肿瘤直径≥4 cm者血清sICAM-1、sVCAM-1水平明显高于肿瘤直径<4 cm者(P<0.01);肿瘤有远处转移者其水平高于无转移者(P<0.01);分化程度低者其水平高于分化成度高者(P<0.01)。胰腺癌患者血清sICAM-1和sVCAM-1水平呈正相关(r=0.964,P<0.01)。结论胰腺癌患者血清sICAM-1s、VCAM-1过度表达,其水平与胰腺癌的侵袭转移密切相关;血清sICAM-1s、VCAM-1水平可作为判断胰腺癌预后的指标。

Objective To explore the expressions of serum intercellular adhesion molecule-（sICAM-1 ） and serum vascular cell adhesion molecule-1 （sVCAM-1）in patients with pancreatic cancer and the value of them. Methods ELESA method was used to measure serum concentration of sICAM-1 and sVCAM-1 in 93 patients with pancreatic cancer,42 Patients with chronic pancreatitis and 51 healthy people. Results The sICAM-1 and sVCAM-1 levels in serum of patients with pancreatic cancer and in patients with pancreatitis were significantly higher than that in health control group（ P 〈0.01）. In the group of patients with chronic pancreatitis, the resuits were significantly lower in comparison with concentration in the group of patients with pancreatic carcinoma （ P 〈0.01）. sICAM-1 and sVCAM-1 values in patients with remote metastases were higher than in patients without metastase（ P 〈0.01）. Conclusion The overexpressions of sICAM-1 and sVCAM-1 are characteristic of chronic pancreatitis and pancreatic carcinoma. The lever of sICAM-1 and sVCAM-1 has a significant relation to the potential of invasion and metastasis in pancreatic carcinoma and may be a new prognostic indicater in pancreatic carcinoma.