含哒嗪酮的五碳糖基碳二亚胺的合成

Synthesis of Pentosyl Carbodiimmides Containing Pyridazinone

2,3,4-三-O-乙酰基-β-D-糖基异硫氰酸酯分别与1,4,5,6-四氢-6-哒嗪酮-3-甲酰肼1和1,6-二氢-6-哒嗪酮-3-甲酰肼2反应,制得4种硫脲,再将硫脲用氧化汞在CHCl3/H2O作用下脱硫化氢,制得新化合物糖基哒嗪酮碳二亚胺1c-1d和2c-2d.化合物的结构经1HNMR,IR确定.

By the reaction of 2,3,4-tri-O-acetyl-β-D-glucosyl isothiocyanate with 1,4,5,6-tetrahydro-6- pyridazinone-3-carboxylic acid hydrazides 1 and 1,6-dihydro-6-pyridazinone-3-Carboxylic acid hydrazides 2 furnished four thioureas. Then these thioureas were desulfurated and transformed into the corresponding glucosyl carbodiimides lc-ld and 2c-2d using HgO in CHCl3/H2O at room temperature. The structures of all compounds have been established by ^1H NMR and IR.