摘要
目的探讨E-钙黏素和β-连环素表达与食管癌患者的临床病理关系。方法对58例食管癌患者术后标本和20例正常食管组织应用PV-6000法检测E-钙黏素和β-连环素的表达。结果 E-钙黏素阳性表达率与食管癌患者癌细胞浸润深度、临床分期显著相关(P<0.01),与癌细胞分化程度、淋巴结转移有关(P<0.05);β-连环素阳性表达率与食管癌患者癌细胞分化程度、临床分期显著相关(P<0.01),与癌细胞浸润深度、淋巴结转移有关(P<0.05)。结论 E-钙黏素及β-连环素与食管癌的浸润和转移相关。
Objective To observe the expression of E-cadherin, β-catenin in human esophageal carcinoma and its relation to clinicopathological features. Methods The expression of E-cadherin and β-catenin was evaluated in the tissues of 58 patients with esophageal carcinoma and 20 people＇s normal esophageal mucosa using immunohistochemical PV method. Results lymph node metastasis （ P clusions E-cadherin and The expression of E-cadherin, β-catenin was significantly related to the invasion depth and 〈 0.01 ） , and to the cell differentition degree and clinical stage of the tumors（ P 〈 0.05 ）. Conclusions expression are correlated with invasion and metastasis of esophageal carcinoma.
出处
《潍坊医学院学报》
2009年第3期222-224,共3页
Acta Academiae Medicinae Weifang
