ZTC1+1天然澄清剂在清开灵口服液制备工艺中的应用

Application of ZTC1+1 natural clarifying agents in Qingkailing oral liquid

目的:考察ZTC1+1天然澄清剂在清开灵口服液中的澄清效果。方法:以清开灵口服液中含氮量为指标,采用正交试验进行优选,找出理想的ZTC1+1天然澄清剂处理工艺,并研究澄清剂在口服液中的残留量。结果:ZTC1+1天然澄清剂既能保留清开灵口服液的有效成分,又能保证制剂的稳定;并与澄清剂的加入次序、反应温度两个因素有关。在清开灵口服液中无ZTC1+1天然澄清剂残留。结论:ZTC1+1天然澄清剂的澄清工艺可代替清开灵口服液的醇沉工艺。

Objective： To study the effect of ZTC1 ＋ 1 natural clarifying agents on the purification of Qingkailing oral liquid. Methods ：The nitrogen content of Qingkailing oral liquid was taken as index. The optimum conditions were obtained by orthogonal ex- perimentations. Results： The result showed that ZTC1 ＋ 1 natural clarifying agents can effectively improve the content of Qingkailing o- ral liquid. The purifying effect was relative to the addition order of ZTC1 ＋ 1 natural clarifying agents and the floeculation temperature. Conclusion：ZTC1 ＋ 1 natural clarifying agents can be used for production of Qingkailing oral liquid.