阿德福韦酯自乳化制剂大鼠体内药动学的初步研究

Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat

目的:研究阿德福韦酯自乳化制剂在大鼠体内的药动学过程。方法:以随机分组组间对照实验设计方法,通过高效液相色谱法测定6只SD大鼠(两组)体内单剂量灌胃服用阿德福韦酯自乳化制剂和片剂100mg/kg后不同时间点的血药浓度,并计算其药动学参数。结果:自乳化制剂组大鼠的Cmax为2.509 4μg/mL,AUC为277.291 1μg.m in/mL);片剂组大鼠的Cmax为1.725 8μg/mL,AUC为215.919 6μg.m in/mL)。结论:阿德福韦酯自乳化制剂的口服生物利用度优于片剂。

Objective ： To study the pharmacokinetics of self-emulsifying drug delivery systems of adefovir dipivoxil in rats. Meth- ods： Six SD rats were randomly divided into two groups for oral administration of the self-emulsifying adefovir dipivoxil and adefovir dipivoxil tablets at a single dose of 100 mg/kg. HPLC method was applied to determine the plasma concentration of these two groups. The calculations Of phannacokinetic parameters were performed with 3 P87 program. Results：For the self-emulsifying adefovir dipivoxil, C^ax and AUC were 2. 509 4 p^g/mL and 277. 291 1 Iμg · min/mL, respectively; while for adefovir sipivoxil tablet, Cmax and AUC were 1. 725 8μg/mL and 215. 919 6 μg ·min/mL, respectively. Conclusions：The oral bioavailability of the self-emulsifying adefovir dipiv- oxil was better than tadefovir dipivoxil tablet.