车前子与车前草利尿作用研究

Effects of the Seeds and Herbs of Plantago asiatica L.on Diuresis

目的观察车前子与车前草提取物的利尿作用。方法采用大鼠水负荷模型,分别用不同浓度的车前子和车前草乙醇提取物和水溶性成分给药,研究并比较其对大鼠排尿量和尿中Na+、K+、C-l离子排泄量的影响。结果40g/kg和10g/kg剂量的车前子和车前草乙醇提取物均能增加大鼠排尿量和尿中Na+、K+、C-l离子含量,相同浓度下车前子作用略强于车前草,但水提物则无利尿作用。结论车前子和车前草具有利尿作用,乙醇提取物为其利尿作用的有效部位,且车前子的利尿作用稍强于车前草。

Objective To study the effects of the extract of the seeds and herbs of Plantago asiatica L. on diuresis. Methods Different concentrations of ethanol and water extracts of the seeds and herbs of Plantago asiatica L. were administered to the water-sodium retention rats, and the urinary outputs and concentrations of Na^＋, K ＋ and Cl^- in urine were determined and compared. Results The dose of 40g/kg and 10g/kg of the ethanol extract of both the seeds and herbs of Plantago asiatica L. could increase the urine volume and the content of Na^＋ , K ^＋ and Cl^ - in urine, while the water extracts couldn＇t. The uretic effect of the seeds of Plantago asiatica L. was more significant than that of the herbs. Conclusion The ethanol exacts of the seeds and herbs of Plantago asiatica L. are the uretic effective fraction.