可必特与沐舒坦联合雾化吸入治疗慢性阻塞性肺疾病急性加重期患者的临床观察

Effects of combivent and mucovent inhalation in the treatment of patients with acute exacerbations of chronic obstructive pulmonary disease

目的观察可必特与沐舒坦联合雾化吸入对慢性阻塞性肺疾病急性加重期患者的临床疗效。方法将98例慢性阻塞性肺疾病急性加重期的住院患者随机分为2组，除常规给予抗生素、氨茶碱、甲强龙等治疗外，对照组49例给予沐舒坦15mg，每日2次雾化吸人，治疗组49例给予沐舒坦15mg，可必特2．5ml联合每日2次雾化吸入。结果两组患者用药7d后症状、体征改善的有效率差异有统计学意义（P〈0．05）；两组氧分压、二氧化碳分压比较差异有统计学意义（P〈0．05）；治疗后肺功能指标（FEV1，FEV1／FVC％）两组比较差异均有统计学意义（P〈0．05）。结论可必特和沐舒坦联合雾化吸入能改善慢性阻塞性肺疾病急性加重期患者的肺功能、临床症状及缓解低氧和二氧化碳潴留。

Objective To investigate the therapeutic effects of combivent and mucovent inhalation in the patientts with acute exacerbations of chronic obstructive pulmonary disease （AECOPD）. Methods Ninety-eight patients with AECOPD were randomly divided into two groups. The basic therapy for the two groups were antibiotics, aminophyline and Solu-Medrol. The treatment group with 49 cases was given 2. 5 ml comhivent and 15 mg mucovent inhalation two times daily, while the control group with 49 cases was treated with 15 mg mucovent only. Results There were not difference in symptom and sign between the two groups before therapy. But on the seventh day between the two groups after therapy,there were significant difference in disappearance rate of symptom and sign （P 〈0. 05）, also, there was significant difference in PaO2, PaCO2 and lung function （ FEV1, FEV1/FVC% ） （ P 〈 0.05 ）. Conclusion As an effective treatment, combivent and mucovent inhalation can relieve the symptom,lung function ,low-oxygen and high-carbon dioxide of patients with acute exacerbations of chronic obstructive pulmonary disease.