微创插植放疗在不能切除胸腹腔恶性肿瘤中的临床应用

Clinical application of micro-invasive implant radiotherapy in unresectable splanchnocoel malignant tumors

目的探讨微创插植放射性125Ⅰ粒子在不能切除的胸腹腔肿瘤中临床应用的可行性。方法回顾性分析96例Ⅲ期肺癌、中晚期肝癌及胰腺癌B超、CT、腔镜等引导插植放疗微创方法的疗效。结果96例病人经治疗后，完全缓解19例，部分缓解39例，无变化21例，继续进展17例，病人生活质量提高，无放射性粒子迁移或排出体外，随访1～5年，存活57例，存活患者中，最长者已达5年，死亡39例。结论微创插植放射性125Ⅰ粒子对中晚期不能切除胸腹腔恶性肿瘤有较好的治疗效果。

Objective To study the feasibility of clinical application of miero-invasive implanted radial 125Ⅰ particle in unresectable splanchnocoel malignant tumors. Methods Retrospective analysis was applied in 96 cases with stage Ⅲlung cancer, or intermediate（advanced） hepatoceUular carcinoma/pancreatic carcinoma who had been treated with micro-invasive implant radiotherapy guided by brightness mode, CT and endoscope. Results After treatment, within 96 eases, there were 19 cases of complete remission, 39 of partial remission, 21 of non-remission and 17 of progression. The life quality of patients was improved, and there was no transfer or discharge of radioactive partides in vitro. The follow-up investigation of patients for 1 - 5 years showed that 39 cases died and 57 cases survived, some of which had reached the maximum 5 years after treatment. Conclusion The micm-invasive implant radial 125Ⅰ particle shows a good therapeutic efficacy in unresectable splanchnocoel malignant tumors of intermediate and advanced stage.