慢性肺心病红细胞免疫功能与氧自由基的关系

The Study of Red Blood Cell Immune Functions and Their Relationship with Oxidative Free Radical in Patients with Chronic Cor Pulmonale

目的：研究慢性肺心病（ＣＣＰ）患者红细胞免疫功能变化及其机制。方法：检测ＣＣＰ患者急性发作期２８例，缓解期２０例的红细胞免疫功能、血清丙二醛（ＭＤＡ）及红细胞超氧化物歧化酶（ＳＯＤ）等指标。结果：ＣＣＰ患者的红细胞Ｃ３ｂ受体花环率（ＲＣ３ｂＲＲ）降低，红细胞免疫复合物花环率（ＲＩＣＲ）增高，ＳＯＤ降低，ＭＤＡ增高，与正常对照组比较差异有显著性，且ＲＣ３ｂＲＲ与ＳＯＤ呈正相关，与ＭＤＡ呈负相关。结论：ＣＣＰ患者存在红细胞免疫功能低下和氧自由基代谢失调，二者是并行发生的，又相互作用与影响，二者之异常很可能继发于呼吸系感染。

Objective: To study the red cell immunological change and their mechanisms of the patients with chronic cor pulmonale (CCP). Methods: the red blood cell immune adherence (RCIARC 3b RR, RICR), and malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in patients with CCP (at) acute exacerbation stage 28 cases, (at) recovery stage 20 cases. Results: Compared with the healthy group, in the patients with CCP acute exacerbation group, recovery group, the activities of RC 3b RR and SOD were significantly decreased, but the RICR, and MDA were increased. The RC 3b RR had a significant positive correlation with SOD, while the RC 3b RR had a negative correlation with RICR, MDA. Conclusion: The patients with CCP suffered from both the dysfunction of RCIA and disturbance of oxidative free radical (OFR) simullaneously and influenced each other, and these changes were likely secondary caused by respiratory infection. By controling infection, the disturbance of RCIA and OFR could be amelioraled.